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When Na modulates Ca: nonlinear interplay between Na/Ca-exchanger and IP3-mediated Ca oscillations in astrocytesтезисы доклада
- Авторы: Verveyko Darya V., Verisokin Andrey Y., Postnov Dmitry E., Brazhe Alexey R.
- Сборник: Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions
- Тезисы
- Год издания: 2019
- Место издания: SPIE
- DOI: 10.1117/12.2523315
- Аннотация: We present a composite model of astrocytic Ca2+ dynamics, which includes both IP3-mediated release from intracellular Ca2+ stores and bidirectional exchange through the plasma membrane, mediated by the Na+/Ca2+- exchanger (NCX). The NCX kinetic model is formulated in the Hodgkin/Huxley formalism, taking into account the glutamate transporter-mediated increase in Na+ during synaptic activity and Na+- and Ca2+-dependent regulation. We define main dynamic regimes and transitions in a point model, describing dynamics in an individual astrocyte segment. We demonstrate NCX-based modulation of store-mediated calcium oscillations (amplitude, frequency and amplitude-frequency), analyze and compare calcium dynamics in models with and without allosteric regulation of NCX by intracellular ions.
- Добавил в систему: Браже Алексей Рудольфович