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Gliotransmitter-based modulation of presynaptic efficacy provides a feedback between neuronal activity and astrocytic transientsтезисы доклада
- Авторы: Verisokin Andrey Y., Lukin Pavel O., Prudkin Maxim N., Verveyko Darya V., Postnov Dmitry E., Brazhe Alexey R.
- Сборник: Computational Biophysics and Nanobiophotonics
- Тезисы
- Год издания: 2022
- Место издания: SPIE
- DOI: 10.1117/12.2626012
- Аннотация: We present a two-dimensional model of astrocytic Ca2+ dynamics. We take into account two main factors of the considered process: the IP3-mediated release from intracellular Ca2+ stores and the plasma membrane bidirectional exchange, i.e. the Na+/Ca2+-exchanger (NCX). We based on the Hodgkin - Huxley formalism to describe NCX effects and takes into account the glutamate transporter-mediated increase in Na+ during synaptic activity and Na+- and Ca2+-dependent regulation. The results of the unified model numerical solution confirm the emergence of calcium waves, which occur due to the synaptic activity and spread over the astrocyte network. The presence of NCX leads to a decrease in the average areas that are affected by a global calcium wave during excitation. However, the Na/Ca exchanger stimulates calcium waves, making possible the formation of more long-lived waves.
- Добавил в систему: Браже Алексей Рудольфович