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[Effects of systemically-administered beta-casomorphin-7 on nociception in rats]статья
Дата последнего поиска статьи во внешних источниках: 24 января 2020 г.
- Авторы: Dubynin V.A., Maklakova A.S., Nezavibat’ko V.N., Alfeeva L.A., Kamenski? A.A., Ashmarin I.P.
- Журнал: Biulleten' eksperimental'no∎ biologii i meditsiny
- Том: 114
- Номер: 9
- Год издания: 1992
- Издательство: Administrativnoia Zdaniia Minzdrava Sssr
- Местоположение издательства: Moskva, Russia (Federation)
- Первая страница: 284
- Последняя страница: 286
- Аннотация: The influence of food-derived heptapeptide beta-casomorphin-7 (beta-CM-7) on pain sensibility of white rats was studied by tail flick test. As shown for doses 10 and 20 mg/kg intraperitoneally, injected beta-CM-7 induced significant analgesia; lower peptide concentration (5 mg/kg) was ineffective. As a whole, there is a significant positive correlation between the intensity of analgesia and the quantity of administered exorphine. These changes of pain sensibility were observed for one hour after injection of heptapeptide; further measurements showed no significant difference of time reaction between control and experimental groups of rats. It was found out that animals with high native level of pain sensibility (4-8 sec) made the main contribution to manifestation of analgesia.
- Добавил в систему: Дубынин Вячеслав Альбертович