Redox active ferrocene-modified pyrimidines and adenine as antitumor agents: strusture, separation of enantiomers, and inhibition of DNA synthesis in tumor cellsстатья
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Дата последнего поиска статьи во внешних источниках: 26 апреля 2017 г.
Аннотация:The structures, electrochemical properties, enantiomeric separation of ferrocenyl
(alkyl)pyrimidines and ferrocenyl(ethyl)adenine and their effects on the DNA synthesis in
tumor cells were studied. Enantiomeric mixtures were separated by HPLC on modified cellulose as the chiral selector. The electrochemical properties of compounds were studied by cyclic
voltammetry. All compounds have reversible singleelectron redox transition in the region of
0.52—0.60 V, which belongs to ferrocene—ferrocenium with a positive shift compared to ferrocene (0.52 V). The molecular structure of 1N-(ferrocenylbenzyl)-5-iodocytosine was studied
by X-ray diffraction. 1N-(Ferrocenylethyl)adenine was studied for ability to inhibit the DNA
synthesis in the human ovarian cancer cell culture by the 3H-thymidine test.