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Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Responseстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 апреля 2024 г.
- Авторы: Sazonov Igor, Grebennikov Dmitry, Savinkov Rostislav, Soboleva Arina, Pavlishin Kirill, Meyerhans Andreas, Bocharov Gennady
- Журнал: Viruses
- Том: 15
- Номер: 2
- Год издания: 2023
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 296
- DOI: 10.3390/v15020296
- Аннотация: A mathematical model of the human immunodeficiency virus Type 1 (HIV-1) life cycle in CD4 T cells was constructed and calibrated. It describes the activation of the intracellular Type I interferon (IFN-I) response and the IFN-induced suppression of viral replication. The model includes viral replication inhibition by interferon-induced antiviral factors and their inactivation by the viral proteins Vpu and Vif. Both deterministic and stochastic model formulations are presented. The stochastic model was used to predict efficiency of IFN-I-induced suppression of viral replication in different initial conditions for autocrine and paracrine effects. The probability of virion excretion for various MOIs and various amounts of IFN-I was evaluated and the statistical properties of the heterogeneity of HIV-1 and IFN-I production characterised.
- Добавил в систему: Бочаров Геннадий Алексеевич