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LIPID PEROXIDATION PRODUCTS AND ENDOGENOUS INTOXICATION LEVELS IN PATIENTS WITH TYPE 1 DIABETES MELLITUS AND DIFFERENT STAGES OF ALBUMINURIAстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Darenskaya M.A., Kolesnikov S.I., Chugunova E.V., Semenova N.V., Kolesnikova L.I.
- Журнал: Diabetes Technology and Therapeutics
- Том: 25
- Номер: S2
- Год издания: 2023
- Издательство: Mary Ann Liebert Inc.
- Местоположение издательства: United States
- Первая страница: A200
- Последняя страница: A200
- DOI: 10.1089/dia.2023.2525.abstracts
- Аннотация: Background and aimsStudies of the pathogenetic mechanisms of the development of disorders at the preclinical stages of diabetic nephropathy are relevant. Therefore, the aim was to study the lipid peroxidation products and endogenous intoxication parameters level in T1DM patients with different stages of albuminuria. This may allow early biomarkers of primary kidney lesions to be set.MethodsA survey of 69 men with T1DM with unsatisfactory glycemic control was carried out. The patients were divided into two groups - with albuminuria A1 stage (A1) - 35 people and albuminuria A2 stage (A2) - 34 people. Spectrophotometric and statistical research methods were used.ResultsThe level of conjugated dienes (CDs) (p=0,003), ketodienes and conjugated trienes (KD and CT) (p=0,019), middle molecular substances (MMS) 238 (by 3.76 times; p<0,0001), MMS 254 (by 1.7 times; p=0,020) in patients with T1DM and A1 stage were significantly higher, than in the control. In patients with T1DM and A2 stage, an increase in CDs (p<0,0001), KD and CT (p<0,0001), MMS 238 (p=0,003) relative to the control values also was noted. The CDs level in the A2 stage was 1.32 times higher (p=0.011) relative to the A1 group data.ConclusionsIn patients with type 1 diabetes, regardless of the stage of albuminuria (A1, A2 stages), oxidative damage to lipids and intensification of endogenous intoxication processes are recorded.
- Добавил в систему: Колесников Сергей Иванович