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DIAGNOSTIC SIGNIFICANCE OF EARLY RENAL MARKERS PODOCALYXIN AND Β-2-MICROGLOBULIN IN PATIENTS WITH TYPE 1 DIABETES MELLITUS Darenskayaстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Kolesnikov S.I.M.A, Chugunova E.V., Lesnaya A.S., Kolesnikova L.I.
- Журнал: Diabetes Technology and Therapeutics
- Том: 25
- Номер: S2
- Год издания: 2023
- Издательство: Mary Ann Liebert Inc.
- Местоположение издательства: United States
- Первая страница: A200
- Последняя страница: A200
- DOI: 10.1089/dia.2023.2525.abstracts
- Аннотация: Background and aimsEarly detection of potentially reversible kidney damage in patients with type 1 diabetes mellitus (T1DM) is extremely important. At the moment, the main groups of early potential renal markers have been identified: tubular markers, markers of podocyte damage, growth factors, etc. The aim of this study was to evaluate the area under the characteristic curve (AUC ROC), sensitivity, and specificity of early renal markers (podocalyxin and β-2-microglobulin) by ROC analysis in men with T1DM and different levels of albuminuria.MethodsIn men with T1DM and early stages of nephropathy (n=69), a comparative analysis of the areas under the characteristic curves (ROC AUC) of early renal markers (podocalyxin and β-2-microglobulin in urine) in comparison with classical parameters (urine albumin and urine albumin/creatinine ratio) using ROC analysis was performed.ResultsIt was found that the values of the area under the curve and the specificity index for podocalyxin were significantly higher (p<0.05) compared with classical renal markers and β-2 - microglobulin. For this parameter, the “cut-off” (associated criterion, split point) was 1.76, which may indicate the likelihood of diabetic nephropathy in the initial stage.ConclusionsIt can be concluded that podocalyxin can be recommended for a differentiated approach to identify risk groups for the development of glomerular kidney disorders in men with type 1 diabetes.
- Добавил в систему: Колесников Сергей Иванович