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8-HYDROXY-2-DEOXYGUANOSINE CONCENTRATION IN MEN WITH TYPE 1 DIABETES MELLITUS AND ALBUMINURIAстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Kolesnikov S.I.M.A, Chugunova E.V., Nikitina O.A., Kolesnikova L.I.
- Журнал: Diabetes Technology and Therapeutics
- Том: 25
- Номер: S2
- Год издания: 2023
- Издательство: Mary Ann Liebert Inc.
- Местоположение издательства: United States
- Первая страница: A236
- Последняя страница: A236
- DOI: 10.1089/dia.2023.2525.abstracts
- Аннотация: Background and aimsCurrently, in all countries of the world there is a rapid increase in the incidence of diabetes mellitus (DM), which in fact becomes a global pandemic. Reactive oxygen species have a damaging effect on the structural components of the cell: lipids, proteins, enzymes and nucleic acids. 8-OHdG is a modified nucleoside base, a by-product of DNA damage. Therefore, the aim was to study the 8-hydroxy-2-deoxyguanosine concentration in men with type 1 diabetes mellitus and albuminuria.MethodsA survey of 69 men with T1DM with unsatisfactory glycemic control was carried out. The patients were divided into two groups - with albuminuria A1 stage (A1) - 35 people and albuminuria A2 stage (A2) - 34 people. The concentration of the DNA destruction indicator - 8-OHdG in blood serum was measured using the commercial Assay Designs' DNA Damage ELISA Kit (USA). Enzyme immunoassay on a MultiSkan ELX808 microplate reader (Biotek, USA) was performed.ResultsStatistically higher values of 8-OH-2-deoxyguanosine were found in the group of patients with type 1 diabetes mellitus at stage A2 in comparison with the control by 1.33 times (p=0.010). Comparison of the results between stages A1 and A2 showed increased values of 8-OHdG by 1.28 times (p=0.010) in patients of group A2.ConclusionsIn men with T1DM, A2 study albuminuria, there are higher values of the oxidative damage DNA parameter, which can be used to develop potential strategies for the prevention and early therapy of diabetic nephropathy.
- Добавил в систему: Колесников Сергей Иванович