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[89Zr]-labeled mesenchymal stem cells biodistribution in rats with local radiation injuriesтезисы доклада Тезисы
- Авторы: Klementyeva O., Luneva K., Larenkov A., Bubenschikov V., Astrelina T., Brunchukov V.
- Сборник: European Association of Nuclear Medicine October 22 – 30, 2020 Virtual
- Том: 47
- Тезисы
- Год издания: 2020
- Место издания: Springer Science and Business Media LLC
- Первая страница: 635
- Последняя страница: 635
- Номер статьи: EP-260
- DOI: 10.1007/s00259-020-04988-4
- Аннотация: The aim of this work: study ofbiodistribution of mesenchymal stem cells (MSC) labeled [89Zr]Zr-oxine in animals at different times after the local irradiation. The local radiation injuries are one of the serious complications of external beam radiation therapy.There is no possible to integrate cellular technologies in the radiation burns treatment without information about the stem cells migration pathways in the body. PET imaging with [89Zr]-labeled stem cells is the most informative method for preclinical studies and clinical applications.Results: The MSC labeling efficiency was about 60%. In the latent phase 89Zr]Zr-oxine-MSC uptake at the RSD site decreased from 82% ID (3h p.i.) to 52% ID (48h p.i.). DUR values was ranged from 66 (3h p.i.) to 151 (48h p.i.). In the acute phase [89Zr]Zr-oxine-MSCs were linked firmly at the RSD site. Uptake levels up to 48 hours after injection were 70-90% ID. Therewere DUR values: 333.4 (3h p.i.), 768.5 (24h p.i.) and 344.8 (48h p.i.). It’s fact suggests about inflammatory response development in the RSD site promotes retention of MSCs.MSCs migration to the liver was observed (up to 2.8% ID 48h p.i.). There was minimal 89Zr uptake in the bone tissue for 48 hours after injection (less 0.4% ID/g).
- Добавил в систему: Клементьева Ольга Евгеньевна