Non-AUG translation initiation in mammalsстатьяИсследовательская статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 февраля 2024 г.
Аннотация:Recent proteogenomic studies revealed extensive translation outside of annotatedprotein coding regions, such as non-coding RNAs and untranslated regions of mRNAs.This non-canonical translation is largely due to start codon plurality within the sameRNA. This plurality is often due to the failure of some scanning ribosomes to recognizepotential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefciency.Here we discuss our current understanding of non-AUG initiation. We argue for a nearubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes.