Аннотация:Introduction: The development of magnetic agents for magnetic fluidhyperthermia application is a complex task requiring simultaneous optimizationof chemical, biomedical, magnetic, and, in particular, thermal properties ofmagnetic nanoparticles (MNPs). In the majority of papers, the magnetothermalmeasurements are carried out on bare MNPs suspended in deionized water withsubsequent optimization of the required physiological and medical properties,including toxicity and biocompatibility. However, in real hyperthermia practice,the stable fluids or colloids of magnetic MNPs are used, and the colloidalstabilization can significantly modify their magnetic properties, includingmagnetothermal ones.Methods: This paper is focused on the study of ZnxMn1-xFe2O4 MNPs stabilized byoleic acid/sodium oleate in this context.Results and Discussion: Our research demonstrates the crucial changes in themagnetic properties and magnetothermal response of ZnMn ferrite MNPsafter the colloidal stabilization: while bare MNPs demonstrate significantcoercivity, nonzero remanent magnetization, and superquadratic dependenceof heat generation on the magnetic field amplitude, the magnetic properties ofcolloidal ZnMn ferrite MNPs are typical for superparamagnetic ones and theirmagnetothermal response is described by a conventional quadratic dependenceon magnetic field amplitude. Various factors such as size distribution, magneticanisotropy, and interparticle dipole–dipole interaction are considered as theorigins of such an impact on magnetic MNPs’ properties.
