Influence of the Tripeptide Corticoliberin Fragment CRF4-6 on Metabolism in RatsстатьяПеревод
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Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.
Аннотация:We report here studies of the effects of the tripeptide corticotropin-releasing factor fragment CRF4-6 on metabolism in rats. Intraventricular administration of 10 μg of tripeptide to anesthetized animals increased metabolic rate without altering the respiratory quotient and induced hyperglycemia and hyperthermia. There were simultaneous increases in heart rate and blood pressure. Changes in the parameters of energy metabolism induced by tripeptide CRF4-6 reproduced the pattern of effects of the full-size corticoliberin molecule. The data obtained here, along with the previously described effects of the tripeptide, suggest that CRF4-6 is a physiologically active regulator derived from corticoliberin, developing and prolonging the effects of the parental molecule.