One-pot Synthesis of Chemical Delivery Systems for Gamma-aminobutyric Acidand its Analogues

Авторы: Semyonkin Aleksey, Zavadovskiy Roman, Polivanova Anna, Abbasova Kenul, Shipulo Elena
Журнал: The open medicinal chemistry journal
Номер: 17
Год издания: 2023
Издательство: Bentham Science Publishers
Местоположение издательства: Netherlands
Первая страница: 1
Последняя страница: 5
DOI: 10.2174/18741045-v17-e230420-2022-3
Аннотация: Introduction:A one-pot synthesis route was proposed for the synthesis of chemical delivery systems of bifunctional compounds containing carboxylic- and amino groups, such as gamma-aminobutyric acid and its structural analogues, gabapentin and phenibutMethods:To obtain targeted compounds, consecutive esterification, amidation, methylation, and reduction were employed in contrast to a more traditional approach that requires isolation and purification of semi-products after each reaction step.Results:A significant (nearly two-fold) increase in yields was observed when target compounds were synthesized using a one-pot approach compared to the conventional one.Conclusion:One-pot approach is a possible and beneficial way for the synthesis of chemical delivery systems for gabapentinoids and other drugs containing carboxylic and amino groups.
Добавил в систему: Аббасова Кенул Расим кызы

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