Plant Poly(ADP-Ribose) Polymerase 1 Is a Potential Mediator of Cross-Talk between the Cajal Body Protein Coilin and Salicylic Acid-Mediated Antiviral Defence

Spechenkova, N.; Samarskaya, V.O.; Kalinina, N.O.; Zavriev, S.K.; MacFarlane, S.; Love, А.J.; Taliansky, M.

Авторы: Spechenkova N., Samarskaya V.O., Kalinina N.O., Zavriev S.K., MacFarlane S., Love А.J., Taliansky M.
Журнал: Viruses
Том: 15
Год издания: 2023
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 1282
Последняя страница: 20
DOI: 10.3390/v15061282
Аннотация: The nucleolus and Cajal bodies (CBs) are sub-nuclear domains with well-known roles inRNA metabolism and RNA-protein assembly. However, they also participate in other importantaspects of cell functioning. This study uncovers a previously unrecognised mechanism by whichthese bodies and their components regulate host defences against pathogen attack. We show thatthe CB protein coilin interacts with poly(ADP-ribose) polymerase 1 (PARP1), redistributes it to thenucleolus and modifies its function, and that these events are accompanied by substantial increasesin endogenous concentrations of salicylic acid (SA), activation of SA-responsive gene expression andcallose deposition leading to the restriction of tobacco rattle virus (TRV) systemic infection. Consistentwith this, we also find that treatment with SA subverts the negative effect of the pharmacologicalPARP inhibitor 3-aminobenzamide (3AB) on plant recovery from TRV infection. Our results suggestthat PARP1 could act as a key molecular actuator in the regulatory network which integrates coilinactivities as a stress sensor for virus infection and SA-mediated antivirus defence.
Добавил в систему: Калинина Наталья Олеговна

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Plant Poly(ADP-Ribose) Polymerase 1 Is a Potential Mediator of Cross-Talk between the Cajal Body Protein Coilin and Salicylic Acid-Mediated Antiviral Defenceстатья

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