Biomimetic Systems Involving Macrophages and Their Potential for Targeted Drug Delivery

Авторы: Savchenko I.V., Zlotnikov I.D., Kudryashova E.V.
Журнал: Biomimetics
Год издания: 2023
Издательство: MDPI Publishing
Местоположение издательства: Basel, Switzerland, Switzerland
DOI: 10.3390/biomimetics8070543
Аннотация: Abstract: The concept of targeted drug delivery can be described in terms of the drug’s ability to mimic the other biological objects’ property to localize to target cells or tissues. For example, drug delivery systems based on red blood cells or mimicking some of their useful features, such as long circulation in stealth mode, have been known for decades. On the contrary, therapeutic strategies based on macrophages have gained very limited attention until recently. Here we review two biomimetic strategies associated with macrophages, that can be used to develop new therapeutic modalities: First, the mimicry of certain types of macrophages (i.e., the use of macrophages, including tumor-associated, or macrophage-like particles as a carrier for targeted delivery of therapeutic agents); and Second, the mimicry of ligands, naturally absorbed by macrophages (i.e., the use of therapeutic agents specifically targeted at macrophages). We discuss potential applications of biomimetic systems involving macrophages for the new advancements in treatment of infections, inflammatory diseases, and cancer.
Добавил в систему: Савченко Иван Витальевич

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