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Revisiting the mystery of centrioles at the beginning of mammalian embryogenesisстатья
- Авторы: Avidor-Reiss Tomer, Uzbekov Rustem
- Журнал: Journal of Assisted Reproduction and Genetics
- Год издания: 2023
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- DOI: 10.1007/s10815-023-02927-4
- Аннотация: The prevailing assumption has been that the human spermatozoon provides only one centriole to the zygote: the proximal centriole, with a canonical, cylinder-like shape. This overly simplistic view has come under challenge since discovering that the human spermatozoon provides a second, atypical centriole to the zygote. The study of human zygotes is challenging for ethical reasons, and bovine zygotes provide an important model due to a similarity in centrosome embryonic inherence and function. Detailed ultrastructural analyses by Uzbekov and colleagues identify the persistence of atypical centrioles in bovine early embryos, raising questions about the original single-centriole model. Whether the parental origin of nascent atypical centrioles or their wide structural diversity and deviation from the canonical centriolar form in blastomeres constitutes sufficient evidence to warrant a reconsideration of the single-centriole model is discussed herein. Because previous human studies identified only one canonical centriole in the zygote, atypical centrioles are likely present in the early human embryo; therefore, it is time to rethink the role of paternal centrioles in human development.
- Добавил в систему: Узбеков Рустем Эдуардович