Аннотация:The objective of this work was to synthesize sulfate-substituted hydroxylapatites NaxCa10-X(P04)6-x(SO4)x(OH)2 by different methods. Samples of dense ceramics were prepared by annealing of porous compacts (with density more than 90% from theoretical). Bioactivity and solubility tests of obtained powders show that anion-modified hydroxylapatites have greater bioactive and resorbable properties then non-modified hydroxylapatites.