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New techniques for pharmacopoeia quality control of mangiferin substanceстатья
- Авторы: Tumasov V., Joseph Nyambose, Morozova M.A.
- Сборник: Archiv Euromedica
- Год издания: 2023
- Первая страница: 26
- Последняя страница: 27
- DOI: 10.35630/2023/XIIsc4hlth/121
- Аннотация: Mangiferin is naturally occurring glucosylxanthone with many pharmacological activities: anti-oxidant, anti-inflammatory, anti-virus, anti-tumor, anti-radiation, antibacterial, hypoglycemic, lowering blood uric acid, protecting the liver and choleretic, im-mune regulation (Naraki et al., 2020). Mangiferin has a wide range of plant sources, but its poor solubility and bioavailability limit its clinical use (Acosta et al., 2016). According to recent research five polymorphs of anhydrous and hydrate mangiferin with different biopharmaceutical properties had been screened and prepared. One of them (amorphous form V) is obtained by mechanical milling and presents the dominant polymorph for the development of innova-tive pharmaceuticals (Yang et al., 2020). Worldwide mangiferin is only used as a component in several traditional Chinese medicines to treat respiratory diseases, but in Russia this substance is registered in the public register of drugs to treat herpes viral infections. So, there is no article on this substance in the world' leading pharmacopoeias. e existing regulatory methods for quality control of mangiferin in Russia do not include assessment of polymorphism or optical activity and in whole are limited by the low solu of the substance in water
- Добавил в систему: Тумасов Владимир Николаевич