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Salt in the wound: A possible role of Na+ gradient in chlamydial infectionстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 5 июня 2017 г.
- Авторы: Dibrov P., Dibrov E., Pierce G.N., Galperin M.Y.
- Журнал: Journal of Molecular Microbiology and Biotechnology
- Том: 8
- Номер: 1
- Год издания: 2004
- Издательство: S. Karger AG
- Местоположение издательства: Switzerland
- Первая страница: 1
- Последняя страница: 6
- DOI: 10.1159/000082075
- Аннотация: Genome analysis has revealed the presence of key components of the Na + chemiosmotic cycle, including the primary Na+ pump (Na+-translocating NADH:ubiquinone oxidoreductase), in the cytoplasmic membrane of two ubiquitous human pathogens, Chlamydia trachomatis and Chlamydiophyla pneumoniae. This observation seemed paradoxical in the case of obligatory intracellular parasites because the Na+ cycle is thought to be primarily a mechanism that enhances the adaptive potential in free-living bacteria that are often facing drastic changes in the salinity and pH of the environment. We present a model suggesting that operation of the Na+ cycle may play an important role in the course of chlamydial infection, when the Na+ and H+ homeostasis of the host cell become severely impaired. This introduces the intriguing possibility of the application of drugs targeting Na+-transporting enzymes to chlamydial infections, which are notoriously difficult to treat. Copyright © 2004 S. Karger AG, Basel.
- Добавил в систему: Galperin Michael Y.