Аннотация:Novel complexes 1-3 of the general formula CuCl2(AbAc)2, CoCl2(AbAc)2 and ZnCl2(AbAc)2 respectively have been synthesized. The structure of compound 2 was confirmed by X-ray diffraction (Fig. 1A). The ability of the compounds to inhibit cell proliferation was examined using the MTT test. It was found that the activity of the obtained compounds against cancer HCT-116, MCF-7, A-549, PC-3 and normal WI-38 cells is comparable to the activity of cisplatin (Fig. 1B). It should be noted that in relation to prostate cancer PC-3cells, complexes 1-3 exhibit a higher activity compared to AbAc, which indicates the effect of the metal on the antiproliferative properties.In addition, compound 2 causes cell cycle arrest in the G0/G1 phase of RNA protein synthesis. The results obtained open up possibilities for further investigation of complexes 1-3 as potential antitumor agents.
