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Antibacterial Bionanocomposites Based on Drug-Templated Bifunctional Mesoporous Silica Nanocontainersстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
- Авторы: Shishmakova E.M., Ivchenko A.V., Bolshakova A.V., Staltsov M.S., Urodkova E.K., Grammatikova N.E., Rudoy V.M., Dement’eva O.V.
- Журнал: Pharmaceutics
- Том: 15
- Номер: 12
- Год издания: 2023
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 2675
- Последняя страница: 2675
- DOI: 10.3390/pharmaceutics15122675
- Аннотация: The creation of antibacterial nanocomposites that provide prolonged release of encapsulateddrugs is of great interest for various fields of medicine (dentistry, tissue regeneration, etc.). This article demonstrates the possibility of creating such nanocomposites based on sodium alginate and drug-templated mesoporous silica nanocontainers (MSNs) loaded with two bioactive substances. Herein, we thoroughly study all stages of the process, starting with the synthesis of MSNs using antiseptic micelles containing the hydrophobic drug quercetin and ending with assessing the activity of the resulting composites against various microorganisms. The main emphasis is on studying the quercetin solubilization in antiseptic micelles as well as establishing the relationship between the conditions of MSN synthesis and micelle morphology and capacity. The effect of medium pH on the release rate of encapsulated drugs is also evaluated. It was shown that the MSNs contained large amounts of encapsulated drugs and that the rate of drug unloading depended on the medium pH. The incorporation of such MSNs into the alginate matrix allowed for a prolonged release of the drugs.
- Добавил в систему: Дементьева Ольга Вадимовна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | pharmaceutics-15-02675_1.pdf | 3,5 МБ | 15 февраля 2024 [anastasia] |