Formation Kinetics and Antimicrobial Activity of Silver Nanoparticle Dispersions Based on N-Reacetylated Oligochitosan Solutions for Biomedical Applicationsстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
Аннотация:The paper presents the results of the synthesis, a detailed kinetics study, and an investigationof the biological activity of silver nanoparticles (AgNPs) in aqueous solutions of N-reacetylatedoligochitosan hydrochloride. UV–visible spectrophotometry and dynamic light scattering wereemployed to control silver ion reduction. The process was observed to follow a pseudo-first-orderlaw. Transmission and scanning electron microscopy demonstrated that AgNPs ranging in sizefrom 10 to 25 nm formed aggregates measuring 60 to 90 nm, with the aggregate surface coated by a2–4 nm chitosan shell. X-ray microanalysis and powder X-ray diffractometry were used to study thephase composition, identifying two crystalline phases, nanocrystalline silver and AgCl, present in thedispersions. The antibacterial effect was assessed using the serial dilution method for dispersionswith varying degrees of Ag+ conversion. Nanodispersions exhibited significant activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, and Staphylococcus aureus. Interestingly, the activity did not appear to be heavily influenced by the presence of the AgCl phase or the concentration of Ag+ ions. These synthesized dispersions hold promise for the development of materials tailored for biomedical applications.