Место издания:Иркутский институт химии им. А.Е. Фаворского СО РАН Иркутск
Первая страница:223
Последняя страница:223
Аннотация:Losartan (HLos) is an antihypertensive agent, increases exercise tolerance in patients with heart failure and prevents sodium and water retention in the body, and its copper complex can inhibit cell proliferation. For novel organotin complexes with losartan of composition Me3SnLos (1), Ph3SnLos (2), Me2Sn(Los)2 (3), Et2Sn(Los)2 (4), Bu2Sn(Los)2 (5), Ph2Sn(Los)2 (6) the antiproliferative activity against colon cancer HCT-116, breast cancer MCF-7, lung cancer A-549, and the diploid human fibroblast cell line WI-38 in comparison with cisplatin was studied.
