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1-(6-bromo-2-chloroquino-3-lyl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ol and its salts Azerbстатья
- Авторы: Kochetkov K.A., Yufriakov V.S., Mammadbeyli E.G., Jafarov I.A.
- Журнал: Azerbaijan Chemical Journal
- Номер: 1
- Год издания: 2024
- Первая страница: 1
- Последняя страница: 5
- Аннотация: Prevention of tuberculosis includes vaccination with the Bacillus Calmette-Guérin (BCG) vaccine, and treatment of this disease requires the use of several antibiotics. In this regard, in recent years there has been the development of new effective treatments for tuberculosis and the improvement of existing drugs. Among the well-known and frequently used anti-tuberculosis drugs, bedaquiline and its derivatives, belonging to the group of diarylquinolines, should be noted. The bactericidal effect of this drug is due to the specific inhibition of the proton pump of mycobacterial ATP synthase (adenosine 5'-triphosphate synthase), an enzyme that plays a major role in the process of cellular respiration of Mycobacterium tuberculosis. Inhibition of ATP synthesis leads to disruption of energy production and, as a result, to the death of the microbial cell. In the presented article, salts of the chlorine analogue of the anti-tuberculosis drug 1-(6-bromo-2-chloroquino-3-lyl)-4-dimethylamino-2-(naphthalene-1-yl)-1-phenylbutan-2-ol (bedaquiline) were obtained from its free base by the action of a number of acids in a two-phase water/methylene dichloride medium. An elemental analysis of the resulting crystalline substances was carried out, the melting point was determined, and the structure of the compounds was confirmed based on IR and NMR spectra.
- Добавил в систему: Кочетков Константин Александрович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Kochetkov_eng.doc | 159,5 КБ | 16 марта 2024 [KochetkovKA] | |
| 2. | акт экспертизы | Mammedbeli_001.jpg | 315,4 КБ | 10 июня 2024 [KochetkovKA] |