|
ИСТИНА |
Войти в систему Регистрация |
ФНКЦ РР |
||
Dose-Dependent Shift in Relative Contribution of Homologous Recombination to DNA Repair after Low-LET Ionizing Radiation Exposure: Empirical Evidence and Numerical Simulationстатья Исследовательская статья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
- Авторы: Belov Oleg, Chigasova Anna, Pustovalova Margarita, Osipov Andrey, Eremin Petr, Vorobyeva Natalia
- Журнал: Current Issues in Molecular Biology
- Том: 45
- Номер: 9
- Год издания: 2023
- Издательство: Caister Academic Press
- Местоположение издательства: United Kingdom
- Первая страница: 7352
- Последняя страница: 7373
- DOI: 10.3390/cimb45090465
- Аннотация: Understanding the relative contributions of different repair pathways to radiation-induced DNA damage responses remains a challenging issue in terms of studying the radiation injury endpoints. The comparative manifestation of homologous recombination (HR) after irradiation with different doses greatly determines the overall effectiveness of recovery in a dividing cell after irradiation, since HR is an error-free mechanism intended to perform the repair of DNA double-strand breaks (DSB) during S/G2 phases of the cell cycle. In this article, we present experimentally observed evidence of dose-dependent shifts in the relative contributions of HR in human fibroblasts after X-ray exposure at doses in the range 20–1000 mGy, which is also supported by quantitative modeling of DNA DSB repair. Our findings indicate that the increase in the radiation dose leads to a dose-dependent decrease in the relative contribution of HR in the entire repair process.
- Добавил в систему: Белов Олег Валерьевич