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Rate of elimination of human high-density lipoproteins after their intravenous administration in rabbits by the loss of alpha- cholesterol and apoprotein A-1статья
- Авторы: Polikarpova L.I., Teriukova N.P., Kalashnikova N.M., Oleĭnik I.A., Klimov A.N.
- Журнал: Vopr Med Khim (Moskva, Russia (Federation))
- Том: 30
- Номер: 6
- Год издания: 1984
- Первая страница: 98
- Последняя страница: 101
- Аннотация: Native HDL, HDL2 or HDL3, isolated from donor plasma were intravenously administered at a large dose (100 mg HDL cholesterol) to healthy rabbits and rabbits with experimental hypercholesterolemia. The elimination rate of human HDL was studied on the basis of alpha-cholesterol (alpha-Ch) and apoprotein (apo) A-I determinations in the plasma of rabbits. Administration of HDL or their subclasses at a large dose with the following determination of alpha-Ch or apo A-I enabled to avoid the use of radioactive label and all the methodological errors connected with the latter. After administration of HDL, HDL2 and HDL3 their elimination according to alpha-Ch determination occurred at the higher rate as compared with apo A-I. Elimination of the total HDL fraction according to alpha-Ch determination was higher in healthy rabbits than in animals with hypercholesterolemia while the elimination estimated by the apo A-I determination was similar in both groups of animals. These data suggest that HDL may characterize the Ch-donor properties. Apo A-I as compared with alpha-Ch was a more accurate indicator of HDL concentration in blood plasma.
- Добавил в систему: Терюкова Наталья Павловна