Prospects of Intravenous CoenzymeQ10 Administration in Emergency Ischemic Conditions

Kalenikova, E.I.; Gorodetskaya, E.A.; Povarova, O.V.; Medvedev, O.S.

Авторы: Kalenikova E.I., Gorodetskaya E.A., Povarova O.V., Medvedev O.S.
Журнал: Preprints
Том: 1
Год издания: 2023
Номер статьи: 2023121073
DOI: 10.20944/preprints202312.1073.v1
Аннотация: Coenzyme CoQ10 (CoQ10) is an endogenous lipid-soluble antioxidant that effectivelyprotects lipids, proteins and DNA from oxidation due to its ability to undergo redox transitionsbetween oxidized and reduced forms. Various oxidative stress-associated infectious and somaticdiseases have been observed to disrupt the balance of CoQ10 concentration in tissues. As a highmolecular weight polar lipophilic compound, CoQ10 exhibits very limited oral bioavailability,which restrains its therapeutic potential. Nevertheless, numerous studies have confirmed theclinical efficacy of CoQ10 therapy through the oral administration of high doses over extended timeperiods. Experimental studies have demonstrated that in emergency situations, intravenousadministration of both oxidized and reduced forms CoQ10 leads to a rapid increase in itsconcentration in organ tissues, offering protection in ischemic conditions for organ tissues. Thissuggests that the cardio- and neuroprotective efficacy of intravenously administered CoQ10 formscould present new opportunities in treating acute ischemic conditions. Based on these findings, thereview provides reasoning supporting further research and implementation of CoQ10 dosage formsfor intravenous administration in emergency situations into clinical practice.
Добавил в систему: Каленикова Елена Игоревна

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Prospects of Intravenous CoenzymeQ10 Administration in Emergency Ischemic Conditionsстатья

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