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Cell stiffness and ROS level alterations in living neurons mediated by β-amyloid oligomers measured by scanning ion-conductance microscopyстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 1 мая 2024 г.
- Авторы: Suchalko Oleg, Timoshenko Roman, Vaneev Alexander, Kolmogorov Vasilii, Savin Nikita, Klyachko Natalia, Barykin Evgeny, Gorbacheva Lyubov, Maksimov Georgy, Kozin Sergei, Erofeev Alexander, Korchev Yuri, Novak Pavel, Edwards Christopher, Majouga Alexander, Makarov Alexander, Gorelkin Peter
- Журнал: Microscopy and Microanalysis
- Том: 27
- Номер: S1
- Год издания: 2021
- Издательство: Cambridge University Press
- Местоположение издательства: United Kingdom
- Первая страница: 500
- Последняя страница: 502
- DOI: 10.1017/S1431927621002270
- Аннотация: Scanning ion-conductance microscopy (SICM) is a scanning probe microscopy technique with nanoscale resolution which allows for the surface topography investigation of nanoscale structures such as living cells in conditions close to physiological (Korchev et al., 1997). Apart from topography visualization, SICM can be used to estimate cell stiffness, which is based on elastic deformation due to colloidal pressure between nanopipette tip and cell surface, and to measure distribution of reactive oxygen species (ROS) concentration in cell.In this work we have investigated alterations in neuron stiffness and ROS level mediated by β-amyloid oligomers. β-amyloids (Aβ) are specific molecules, which form amyloid plaques in human brain and are considered responsible for Alzheimer disease (AD) development (Holmes et al., 2008). Of all Aβ isoforms, Aβ-42 has been most studied and is also widely accepted as main
- Добавил в систему: Горбачева Любовь Руфэльевна