USE OF HEPATOPROTECTORS IN PATIENTS WITH OVARIAN CANCERстатья
Статья опубликована в журнале из списка RSCI Web of Science
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 января 2024 г.
Аннотация:Objective: to evaluate the efficiency of pharmacological correction of endogenous intoxication in patients with Stages III-IV ovarian cancer (OC) in the perioperative period. Subjects and methods. Thirty-to-70-year-old seventy patients with Stages III-IV OC who had been surgically treated under general anesthesia were examined. The biochemical parameters of intoxication, such as middle-weight molecules, the total, effective concentration and binding capacity of albumin, integral hematological indices of intoxication, and C-reactive protein, were studied in the perioperative period.Results. Analysis of the performed tests showed that the premorbid background in all the examinees was characterized by varying degrees of endogenous intoxication (EI), increased leukocytic index of intoxication, hematological index of intoxication, and modified hematological index of intoxication, an imbalance between the accumulation and binding of overproduced toxic ligands, the intensified production of acute-phase inflammatory proteins by the activation of a systemic inflammatory response, and decreased systemic responsiveness...