Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy

Gorshinova, V.K.; Tsvirkun, D.V.; Sukhanova, I.A.; Tarasova, N.V.; Volodina, M.A.; Marey, M.V.; Smolnikova, V.U.; Vysokikh, M.Y.; Sukhikh, G.T.

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 сентября 2017 г.

Авторы: Gorshinova Victoria K., Tsvirkun Daria V., Sukhanova Iuliia A., Tarasova Nadezhda V., Volodina Maria A., Marey Maria V., Smolnikova Veronika U., Vysokikh Mikhail Yu, Sukhikh Gennady T.
Журнал: BBA Clinical
Том: 7
Год издания: 2017
Первая страница: 141
Последняя страница: 146
DOI: 10.1016/j.bbacli.2017.03.005
Аннотация: Most studies have considered the negative influence of obesity on fertility in both genders. In the present study, we assessed mitochondrial activity expressed as the mitochondrial potential index (MPI) in cumulus cells from obese women and women with a normal body mass index (BMI) during assisted reproductive therapy. The results revealed a significant reduction of MPI with increased body mass. The lower MPI levels in cumulus cells from obese women may reflect mitochondrial dysfunction caused by oxidative stress, which can affect the cumulus-oocyte complex and have an impact on oocyte development. Results of our study support a concept that obesity leads to mitochondrial dysfunction. In cumulus cells, mitochondrial dysfunction can reflect or even significantly affect the oocyte energy supply and contribute to the reduced oocyte quality and pregnancy rates for women with obesity. A better understanding of the energetic relationships in cumulus-oocyte complex can provide a new approach for better quality oocyte selection and assist the optimization of IVF implementation. Keywords Cumulus cells; Obesity; Adipokines; Mitochondria; Mitochondrial potential; IVF
Добавил в систему: Высоких Михаил Юрьевич

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Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapyстатья

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