BDNF, DRD4, and HTR2A Gene Allele Frequency Distribution and Association with Mental Illnesses in the European Part of Russia

Morozova, A.; Ushakova, V.; Pavlova, O.; Bairamova, S.; Andryshenko, N.; Ochneva, A.; Abramova, O.; Zorkina, Y.; Spektor, V.A.; Gadisov, T.; Ukhov, A.; Zubkov, E.; Solovieva, K.; Alexeeva, P.; Khobta, E.; Nebogina, K.; Kozlov, A.; Klimenko, T.; Gurina, O.; Shport, S.; Kostuyk, G.; Chekhonin, V.; Pavlov, K.

Авторы: Morozova Anna, Ushakova Valeriya, Pavlova Olga, Bairamova Sakeena, Andryshenko Nika, Ochneva Aleksandra, Abramova Olga, Zorkina Yana, Spektor Valery A., Gadisov Timur, Ukhov Andrey, Zubkov Eugene, Solovieva Kristina, Alexeeva Polina, Khobta Elena, Nebogina Kira, Kozlov Alexander, Klimenko Tatyana, Gurina Olga, Shport Svetlana, Kostuyk George, Chekhonin Vladimir, Pavlov Konstantin
Журнал: Genes
Том: 15
Номер: 2
Год издания: 2024
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 240
DOI: 10.3390/genes15020240
Аннотация: The prevalence of mental disorders and how they are diagnosed represent some of the major problems in psychiatry. Modern genetic tools offer the potential to reduce the complications concerning diagnosis. However, the vast genetic diversity in the world population requires a closer investigation of any selected populations. In the current research, four polymorphisms, namely rs6265 in BDNF, rs10835210 in BDNF, rs6313 in HTR2A, and rs1800955 in DRD4, were analyzed in a case–control study of 2393 individuals (1639 patients with mental disorders (F20-F29, F30-F48) and 754 controls) from the European part of Russia using the TaqMan SNP genotyping method. Significant associations between rs6265 BDNF and rs1800955 DRD4 and mental impairments were detected when comparing the general group of patients with mental disorders (without separation into diagnoses) to the control group. Associations of rs6265 in BDNF, rs1800955 in DRD4, and rs6313 in HTR2A with schizophrenia in patients from the schizophrenia group separately compared to the control group were also found. The obtained results can extend the concept of a genetic basis for mental disorders in the Russian population and provide a basis for the future improvement in psychiatric diagnostics.
Добавил в систему: Костюк Георгий Петрович

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BDNF, DRD4, and HTR2A Gene Allele Frequency Distribution and Association with Mental Illnesses in the European Part of Russiaстатья