A matter of new life and cell death: programmed cell death in the mammalian ovary

Chesnokov, M.S.; Mamedova, A.R.; Zhivotovsky, B.; Kopeina, G.S.

Авторы: Chesnokov Mikhail S., Mamedova Aygun R., Zhivotovsky Boris, Kopeina Gelina S.
Журнал: Journal of Biomedical Science
Том: 31
Номер: 1
Год издания: 2024
Издательство: S. Karger AG
Местоположение издательства: Switzerland
Первая страница: 31
DOI: 10.1186/s12929-024-01017-6
Аннотация: Background: The mammalian ovary is a unique organ that displays a distinctive feature of cyclic changes throughout the entire reproductive period. The estrous/menstrual cycles are associated with drastic functional and morphological rearrangements of ovarian tissue, including follicular development and degeneration, and the formation and subsequent atrophy of the corpus luteum. The flawless execution of these reiterative processes is impossible without the involvement of programmed cell death (PCD).Main text: PCD is crucial for efficient and careful clearance of excessive, depleted, or obsolete ovarian structures for ovarian cycling. Moreover, PCD facilitates the selection of high-quality oocytes and the formation of the ovarian reserve during embryonic and juvenile development. Disruption of PCD regulation can heavily impact ovarian functions and is associated with various pathologies, from a moderate decrease in fertility to severe hormonal disturbance, complete loss of reproductive function, and tumorigenesis. This comprehensive review aims to provide updated information on the role of PCD in various processes occurring in normal and pathologic ovaries. Three major events of PCD in the ovary-progenitor germ cell depletion, follicular atresia, and corpus luteum degradation are described, alongside the detailed information on the molecular regulation of these processes, highlighting the contribution of apoptosis, autophagy, necroptosis, and ferroptosis. Ultimately, the current knowledge of PCD aberrations associated with pathologies, such as polycystic ovarian syndrome, premature ovarian insufficiency, and tumors of ovarian origin, is outlined.Conclusion: PCD is an essential element in ovarian development, functions, and pathologies. A thorough understanding of molecular mechanisms regulating PCD events is required for future advances in the diagnosis and management of various disorders of the ovary and the female reproductive system in general.
Добавил в систему: Животовский Борис Давидович

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A matter of new life and cell death: programmed cell death in the mammalian ovaryстатья

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