Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties

Shabatina, T.I.; Gromova, Y.A.; Vernaya, O.I.; Soloviev, A.V.; Shabatin, A.V.; Morosov, Y.N.; Astashova, I.V.; Melnikov, M.Y.

Авторы: Shabatina Tatyana I., Gromova Yana A., Vernaya Olga I., Soloviev Andrei V., Shabatin Andrei V., Morosov Yurii N., Astashova Irina V., Melnikov Michail Y.
Журнал: Pharmaceuticals
Том: 17
Год издания: 2024
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 587
DOI: 10.3390/ph17050587
Аннотация: Submission received: 25 March 2024 / Revised: 16 April 2024 / Accepted: 25 April 2024 / Published: 5 May 2024The use of medicinal substances in nanosized forms (nanoforms, nanoparticles) allows the therapeutic effectiveness of pharmaceutical preparations to be increased due to several factors: (1) the high specific surface area of nanomaterials, and (2) the high concentration of surface-active centers interacting with biological objects. In the case of drug nanoforms, even low concentrations ofa bioactive substance can have a significant therapeutic effect on living organisms. These effects allow pharmacists to use lower doses of active components, consequently lowering the toxic side effects of pharmaceutical nanoform preparations. It is known that many drug substances that are currently in development are poorly soluble in water, so they have insufficient bioavailability. Converting them into nanoforms will increase their rate of dissolution, and the increased saturation solubility of drug nanocrystals also makes a significant contribution to their high therapeutic efficiency. Somephysical and chemical methods can contribute to the formation of both pure drug nanoparticlesand their ligand or of polymer-covered nanoforms, which are characterized by higher stability. Thisreview describes the most commonly used methods for the preparation of nanoforms (nanoparticles)of different medicinal substances, paying close attention to modern supercritical and cryogenictechnologies and the advantages and disadvantages of the described methods and techniques;moreover, the improvements in the physico-chemical and biomedical properties of the obtainedmedicinal nanoforms are also discussed.
Добавил в систему: Мельников Михаил Яковлевич

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