Functional Design of Peroral Iron Compound Delivery Systems Based on Polymethylsilsesquioxane Hydrogels for the Therapy of Iron Deficiency Anemia

Авторы: Orlova Polina, Meshkov I.B., Latipov E.V., Vasil’ev S.G., Kalinina A.A., Muzafarov A.M., Le-Deygen I.M.
Журнал: Russian Journal of Inorganic Chemistry
Том: 69
Номер: 4
Год издания: 2024
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 428
Последняя страница: 438
DOI: 10.1134/S0036023624600266
Аннотация: An approach to the development of peroral iron drug delivery systems for the therapy of iron deficiency anemia is proposed. The new systems are based on polymethylsilsesquioxane hydrogels with a variablestructure as biocompatible and biodegradable supports. The hydrogels are found to exhibit a high sorptioncapacity toward a saturated solution of FeCl3∙6H2O (0.27 M), whereas the sorption capacity toward a saturated solution of iron D-gluconate (0.24 M) is lower and amounts to ~30%. The developed delivery systemsare studied by IR and UV spectroscopy, and the iron atom distribution over the hydrogels is studied. The prepared systems are found to be promising for the further development of drug formulations.
Добавил в систему: Ле-Дейген Ирина Михайловна

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