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Gut Microbiota and Liver Regeneration: A Synthesis of Evidence on Structural Changes and Physiological Mechanismsстатья
- Авторы: Kiseleva Y., Zharikova T., Maslennikov R., Temirbekov S., Olsufieva A., Polyakova O., Pontes-Silva A., Zharikov Y.
- Журнал: Journal of clinical and experimental hepatology
- Год издания: 2024
- Издательство: Reed Elsevier India
- Местоположение издательства: Gurgaon, India
- DOI: 10.1016/j.jceh.2024.101455
- Аннотация: Liver regeneration (LR) is a unique biological process with the ability to restore up to 70% of the organ. This allows for the preservation of liver resections for various liver tumors and for living donor transplantation. However, in some cases, LR is insufficient and interventions that can improve LR are urgently needed. Gut microbiota (GM) is one of the factors influencing LR, as the liver and intestine are intimately connected through the gut-liver axis. Thus, healthy GM supports normal LR, whereas dysbiosis leads to impaired LR due to imbalance of bile acids, inflammatory cytokines, microbial metabolites, signaling pathways, etc. Therefore, GM can be considered as a new possible therapeutic target to improve LR. In this review, we observe the current knowledge about the influence of GM on LR and the possibility to improve this process, which may reduce complication and mortality rates after liver surgery. Although much research has been done on this topic, more clinical trials and systemic reviews are urgently needed to move this type of intervention from the experimental to the clinical field.
- Добавил в систему: Жарикова Татьяна Сергеевна