Supramolecular System Based on Hexamolybdenum Cluster Complexes in the Determination of Amitriptyline in Human Urine Using Amperometric Immunosenors

Brusnitsyna, D.V.; Medyantsevaa, E.P.; Ramazanova, A.N.; Prytkova, A.V.; Karimova, E.R.; Elistratova, Y.G.; Mustafina, A.R.; Sokolov, M.N.; Eremin, S.A.; Mukhametova, L.I.

Авторы: Brusnitsyna D.V., Medyantsevaa E.P., Ramazanova A.N., Prytkova A.V., Karimova E.R., Elistratova Yu G., Mustafina A.R., Sokolov M.N., Eremin S.A., Mukhametova L.I.
Журнал: Journal of Analytical Chemistry
Том: 79
Номер: 6
Год издания: 2024
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 726
Последняя страница: 732
DOI: 10.1134/S1061934824700102
Аннотация: A method for the determination of amitriptyline, a tricyclic antidepressant, in human urine byimmunosensors has been developed using supramolecular systems based on hexamolybdenum cluster complexes. These complexes have electrochemical activity and give a stable analytical signal, which was used inthe development of amperometric immunosensors. Luminescence and dynamic light scattering methodswere used to demonstrate the formation of a supramolecular system of self-organized hexamolybdenum nanoparticles and chitosan molecules. A composite material based on hexamolybdenum cluster complexes in combination with reduced graphene oxide has been developed. The working range of amitriptyline concentrationsto be determined by an amperometric immunosensor was 1 × 10–9–1 × 10–4 M, the limit of determination was at a level of 5 × 10–10 M, and the amitriptyline content of urine samples was at a level of (n – 7) × 10–8 M. A comparison of the results of analysis performed using an amperometric immunosensor and a fluorescence polarization immunoassay showed the absence of significant systematic errors. The ability to determine amitriptyline in biological fluids makes it possible to select an optimal therapeutic dose of the drug, that is, to developapproaches to creating personalized medicine.
Добавил в систему: Мухаметова Лилия Инилевна

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Supramolecular System Based on Hexamolybdenum Cluster Complexes in the Determination of Amitriptyline in Human Urine Using Amperometric Immunosenorsстатья Исследовательская статья

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