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New 1,1-dibenzyl-3-(1-benzyl-1H-pyrazol-4-yl)-2-methylisothioureas: synthesis and evaluation of antioxidant activityстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 июля 2024 г.
- Авторы: Proshin A.N., Trofimova T.P., Globa A.A., Dubrovskaya E.S., Zefirova O.N., Zefirov N.A., Tafeenko V.A., Dutova T.Ya, Ugrak B.I., Serkov I.V.
- Журнал: Russian Chemical Bulletin
- Том: 73
- Номер: 5
- Год издания: 2024
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 1399
- Последняя страница: 1407
- DOI: 10.1007/s11172-024-4258-y
- Аннотация: 1,1-Dibenzyl-3-(1-benzyl-1H-pyrazol-4-yl)-2-methylisothioureas containing structural elements both of known antioxidants and glutamate receptor modulators were proposed as compounds with a dual mode of biological action, namely the antioxidant activity and the ability to influence the glutamatergic signaling system. The target compounds were synthesized by the reaction of substituted 4-amino-1-benzylpyrazoles with thiophosgene followed by the condensation of the resulting 1-benzyl-4-isothiocyanato-1H-pyrazoles with dibenzylamine and the subsequent S-methylation of the resulting thioureas. 1,1-Dibenzyl-3-[1-(3,4-dichlorobenzyl)- and 1,1-dibenzyl-3-[1-(2,4-dichlorobenzyl)-1H-pyrazol-4-yl]-2-methylisothioureas were found to have a moderate ability to protect neuroblastoma cells against the toxic eff ect of hydrogen peroxide, making these compounds interesting for further study of the modulatory activity toward glutamate receptors.
- Добавил в систему: Зефирова Ольга Николаевна