First Insight into the Degradome of Aspergillus ochraceus: Novel Secreted Peptidases and Their Inhibitors

Shestakova, A.A.; Fatkulin, A.A.; Surkova, D.E.; Osmolovskiy, A.A.; Popova, E.A.

Авторы: Shestakova A.A., Fatkulin A.A., Surkova D.E., Osmolovskiy A.A., Popova E.A.
Журнал: International Journal of Molecular Sciences
Том: 25
Номер: 13
Год издания: 2024
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 1
Последняя страница: 27
Номер статьи: 7121
DOI: 10.3390/ijms25137121
Аннотация: Aspergillus fungi constitute a pivotal element within ecosystems, serving as both contributors of biologically active compounds and harboring the potential to cause various diseases across living organisms. The organism’s proteolytic enzyme complex, termed the degradome, acts as an intermediary in its dynamic interaction with the surrounding environment. Using techniques such as genome and transcriptome sequencing, alongside protein prediction methodologies, we identified putative extracellular peptidases within Aspergillus ochraceus VKM-F4104D. Following manual annotation procedures, a total of 11 aspartic, 2 cysteine, 2 glutamic, 21 serine, 1 threonine, and 21 metallopeptidases were attributed to the extracellular degradome of A. ochraceus VKM-F4104D. Among them are enzymes with promising applications in biotechnology, potential targets and agents for antifungal therapy, and microbial antagonism factors. Thus, additional functionalities of the extracellular degradome, extending beyond mere protein substrate digestion for nutritional purposes, were demonstrated.
Добавил в систему: Попова Елизавета Андреевна

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First Insight into the Degradome of Aspergillus ochraceus: Novel Secreted Peptidases and Their Inhibitorsстатья

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