Enhanced low beta activity in Park2-associated Parkinson’s disease

Filyushkina, V.; Sayfulina, K.; Gamaleya, A.; Tomskiy, A.; Belova, E.; Sedov, A.

Авторы: Filyushkina V., Sayfulina K., Gamaleya A., Tomskiy A., Belova E., Sedov A.
Журнал: Parkinsonism and Related Disorders
Том: 122
Год издания: 2024
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 62
Последняя страница: 62
Номер статьи: 106745
DOI: 10.1016/j.parkreldis.2024.106745
Аннотация: Background: It is believed that early onset Parkinson's disease may be triggered by genetic mutations, such as PARK2. However, not all patients with early onset exhibit these mutations. It is conceivable that such mutations influence the activity of subcortical structures, potentially necessitating a different therapeutic approach for these patients, such as alterations in stimulation area or structure.Methods: In our study, four patients with early-onset Parkinson's disease were included (two with PARK2 mutation and two without). We analyzed local potentials (LFP) recorded from externalized electrodes for deep brain stimulation (DBS) located in the subthalamic nucleus. LFP and EMG recording were performed at rest state and during voluntary movements before (OFF-state) and after (ON-state) L-Dopa treatment. We used FOOOF approach and wavelet transform for data analysis.Results: We found that patients with the PARK2 gene characterized by two high amplitude peaks in low and high beta ranges while non-PARK2 patients characterized by single wide peak of beta activity. Low beta activity was totally suppressed and no differences in high beta activity was observed after L-dopa in PARK2. At the same time we observed high beta desynchronization and no significant changes in low beta activity during voluntary movements.Conclusions: We showed enhanced low beta activity in PARK2 patients which was sensitive to L-dopa and high beta activity which was sensitive to voluntary movement. The small sample size is a significant limitation for making meaningful conclusions. Further study of the influence of genetic factors on the pathophysiology of Parkinson's disease will enable us to develop more effective and personalized treatment strategies for this condition.The study was funded by the Russian Science Foundation (22-15-00344).
Добавил в систему: Гамалея Анна Александровна

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