Theta-alpha STN oscillations are associated with motor signs of Parkinson’s disease

Sayfulina, K.; Gamaleya, A.; Filyushkina, V.; Tomskiy, A.; Belova, E.; Sedov, A.

Авторы: Sayfulina K., Gamaleya A., Filyushkina V., Tomskiy A., Belova E., Sedov A.
Журнал: Parkinsonism and Related Disorders
Том: 122
Год издания: 2024
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 85
Последняя страница: 85
Номер статьи: 106818
DOI: 10.1016/j.parkreldis.2024.106818
Аннотация: Background: Subthalamic beta oscillations (12-35 Hz) are thought to be associated with the motor symptoms of PD. However, several studies showed that neural activity in lower frequency ranges correlates with motor symptoms, although evidence on functions of STN theta-alpha oscillations is contradictory. This study aims to investigate the relationship between motor PD symptoms and STN oscillatory activity using the approach of extracting oscillatory peaks with maximum amplitude.Methods: Fourteen PD patients underwent bilateral STN DBS surgery with temporary leads externalization. LFPs were recorded during the rest in OFF and ON state several days after the surgery. Motor symptoms were assessed using UPDRS scale. LFPs were processed using scripts based on MNE Python. We obtained 15 bipolar LFPs for each hemisphere by subtraction of 8 neighboring monopolar pairs. We calculated power spectral density in the range 5-35 Hz and extracted oscillatory peaks by removing an aperiodic component of the spectrum. Cluster analysis was used to group peaks based on peak amplitude, peak width and peak frequency, and linear mixed models were applied to test the relationship between motor signs and peak amplitude.Results: Cluster analysis revealed three clusters of peaks, belonging to ranges 5-12, 12-22 and 22-35 Hz. The amplitude of maximum oscillatory peaks in the 5-12 Hz range in OFF-state was positively associated with tremor (p<0.001), bradykinesia (p=0.005), and total UPDRS III (p=0.001), whereas the 12-22 Hz range showed an association with tremor only (p = 0.03).Conclusions: We found an association with motor symptoms of the amplitude of STN maximal oscillatory peaks in the 5-12 Hz range in OFF state. Our results suggest that the theta-alpha range, when analyzed by selecting peaks with maximum amplitude, is associated not only with tremor, but also with bradykinesia and with the total motor impairment score. The study was funded by the Russian Science Foundation (22-15-00344).
Добавил в систему: Гамалея Анна Александровна

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