Effects of Bis(imino)acenaphthene (Bian)-Derived Ligands on the Cytotoxicity, DNA  Interactions, and Redox Activity of Palladium(II) Bipyridine Complexes

Komlyagina, V.I.; Romashev, N.F.; Besprozvannykh, V.K.; Arakelyan, J.; Wu, C.; Chubarov, A.S.; Bakaev, I.V.; Soh, Y.K.; Abramov, P.A.; Cheung, K.L.; Kompan’kov, N.B.; Ryadun, A.A.; Babak, M.V.; Gushchin, A.L.

Авторы: Komlyagina Veronika I., Romashev Nikolai F., Besprozvannykh Victoria K., Arakelyan Jemma, Wu Chengnan, Chubarov Alexey S., Bakaev Ivan V., Soh Yee Kiat, Abramov Pavel A., Cheung Kin Leung, Kompan’kov Nikolai B., Ryadun Aleksey A., Babak Maria V., Gushchin Artem L.
Журнал: Inorganic Chemistry
Том: 62
Номер: 29
Год издания: 2023
Издательство: American Chemical Society
Местоположение издательства: United States
Первая страница: 11541
Последняя страница: 11553
DOI: 10.1021/acs.inorgchem.3c01172
Аннотация: A series of heteroleptic bipyridine Pd(II) complexes based on 1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene (dpp-Bian) or 1,2-bis[(2,4,6-trimethylphenyl)imino]acenaphthene (tmp-Bian) were prepared. All complexes were fully characterized by spectrochemical methods, and their crystal structures were confirmed by X-ray diffraction analysis. The 72 h stability of heteroleptic bipyridine Pd(II) complexes with Bian ligands under physiological conditions was investigated using 1H NMR spectroscopy. The anticancer activity of all complexes was assessed in a panel of cancer cell lines in comparison with uncoordinated ligands and clinically used drugs cisplatin and doxorubicin. The ability of the complexes to bind DNA was investigated using several methods, including EtBr replacement assay, density functional theory calculations, circular dichroism spectroscopy, DNA gel electrophoresis, and TUNEL assay. The electrochemical activity of all complexes and the uncoordinated ligands was studied using cyclic voltammetry, and reactive oxygen species production in cancer cells was investigated using confocal microscopy. Heteroleptic bipyridine PdII-Bian complexes were cytotoxic in a low micromolar concentration range and showed some selectivity toward cancer cells in comparison with noncancerous MRC-5 lung fibroblasts.
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Effects of Bis(imino)acenaphthene (Bian)-Derived Ligands on the Cytotoxicity, DNA Interactions, and Redox Activity of Palladium(II) Bipyridine Complexesстатья