1,3-Dipolar Cycloaddition of Diazophosphonates with Methyl(Ethyl) Acrylate for the Synthesis of 5-Arylpyrazole-3-carboxylates

Авторы: Titanyuk Igor D., Zinovyev Nikolay A., Beletskaya Irina P.
Журнал: SYNTHESIS-STUTTGART
Том: 56
Номер: 17
Год издания: 2024
Издательство: Georg Thieme Verlag
Местоположение издательства: Germany
Первая страница: 2687
Последняя страница: 2694
DOI: 10.1055/a-2338-8631
Аннотация: A wide range of -aryl--diazophosphonates was easily prepared via modified diazo transfer reaction. Benzylphoshonates reacted with tosyl azide (TsN3) in the presence of potassium tert-butoxide (KOtBu) to afford diazophosphonates in yields up to 93% (generally 70-80%). Aryl-diazophosponates were successfully explored for the synthesis of 5-aryl substituted pyrazol-3-carboxylates in one pot by the 1,3-dipolar cycloaddition with alkyl acrylates followed by NaH treatment. The second stage led to elimination of the diethoxylphosphoryl moiety with the aromatization of cycle.
Добавил в систему: Титанюк Игорь Демьянович

	ИСТИНА	Войти в систему Регистрация
	ФНКЦ РР
	Главная Поиск Статистика О проекте Помощь

ИСТИНА