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A novel unconventional T cell population enriched in Crohn’s diseaseстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Rosati Elisa, Rios Martini Gabriela, Pogorelyy Mikhail V., Minervina Anastasia A., Degenhardt Frauke, Wendorff Mareike, Sari Soner, Mayr Gabriele, Fazio Antonella, Dowds Christel Marie, Hauser Charlotte, Tran Florian, von Schönfels Witigo, Pochhammer Julius, Salnikova Maria A., Jaeckel Charlot, Gigla Johannes Boy, Sabet Sanaz Sedghpour, Hübenthal Matthias, Schiminsky Esther, Schreiber Stefan, Rosenstiel Philip C., Scheffold Alexander, Thomas Paul G., Lieb Wolfgang, Bokemeyer Bernd, Witte Maria, Aden Konrad, Hendricks Alexander, Schafmayer Clemens, Egberts Jan-Hendrick, Mamedov Ilgar Z., Bacher Petra, Franke Andre
- Журнал: Gut
- Том: 71
- Номер: 11
- Год издания: 2022
- Издательство: BMJ Publishing Group
- Местоположение издательства: United Kingdom
- Первая страница: 2194
- Последняя страница: 2204
- DOI: 10.1136/gutjnl-2021-325373
- Аннотация: We identified a group of clonotypes, characterised by semi-invariant TCR alpha chains, to be significantly enriched in the blood of patients with Crohn's disease (CD) and particularly expanded in the CD8+ T cell population. Single-cell RNAseq data showed an innate-like phenotype of these cells, with a comparable gene expression to unconventional T cells such as mucosal associated invariant T and natural killer T (NKT) cells, but with distinct TCRs.
- Добавил в систему: Сальникова Мария Алексеевна