Organotin carboxylates with bulky substituents. Synthesis, structure, cytotoxicity and antioxidant activity

Nikitin, E.; Fedorov, S.; Gracheva, Y.; Lyssenko, K.; Semykin, A.; Oprunenko, Y.; Sobolev, N.; Mazur, D.; Dubova, L.; Shevtsova, E.; Milaeva, E.

Авторы: Nikitin Evgeny, Fedorov Stanislav, Gracheva Yulia, Lyssenko Konstantin, Semykin Artem, Oprunenko Yury, Sobolev Nikita, Mazur Dmitrii, Dubova Ludmila, Shevtsova Elena, Milaeva Elena
Журнал: Inorganica Chimica Acta
Том: 574
Год издания: 2025
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Номер статьи: 122388
DOI: 10.1016/j.ica.2024.122388
Аннотация: A series of organotin carboxylates were synthesized and characterized by NMR (1H, 13C, 119Sn) and IR spec-troscopy, ESI mass-spectrometry and elemental analysis. The structure of two compounds was resolved directly using X-ray diffraction analysis and unusual heptacoordinated Sn coordination polyhedron was discovered for them. Anti-oxidant activity of the synthesized compounds was estimated using DPPH, NBT and CUPRAC-tests, lipid peroxida-tion and lipoxygenase inhibition capacity as well. It was shown that the presence of the hydroxyl group in the aromatic ring of the ligand drastically increases antioxidant potency of the complexes, while not noticeably affecting the anti-proliferative properties, which were measured with the standard MTT-test. Moreover, it was shown that derivatives of dibutyl- and di-tert-butyltin exhibit the highest cytotoxicity. Three complexes were put forward as lead compounds and additional apoptosis induction studies were carried out. Noticeable caspase activation was shown for the complexes 4 and 7 thus marking their mode of action. The results obtained show that the complexes herein described are promising antiproliferative agents.
Добавил в систему: Никитин Евгений Александрович

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