Slow Negative Potentials in the Pre-Stimulus Period in Healthy Subjects and Patients with their First Episode of Schizophrenia

Slavutskaya, M.V.; Lebedeva, I.S.; Fedotova, A.A.; Tikhonov, D.V.; Kaleda, V.G.

Авторы: Slavutskaya M.V., Lebedeva I.S., Fedotova A.A., Tikhonov D.V., Kaleda V.G.
Журнал: Human Physiology
Том: 50
Номер: 3
Год издания: 2024
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 209
Последняя страница: 218
Номер статьи: 2470069
DOI: 10.1134/S0362119724700695
Аннотация: Behavioral data (number and nature of erroneous responses, LP of saccades to the “Go” stimulus)indicate a significant decrease in the efficiency of task performance in patients with their first episode ofschizophrenia, compared to healthy subjects. At the same time, in the group of patients, an increase in theamplitude of the slow negativity components (SNP1, SNP2, SNP3) in the 1-s pre-stimulus interval wasshown, which may reflect a compensatory increase in the activation of the cortical networks of predictiveattention and proactive inhibition to improve the effectiveness of the response. Intergroup differences in thetopography of the peaks of the SNP1 and 2 components suggest “disorganization” of the cortical networks ofcognitive control of the left hemisphere at an early stage of schizophrenia. It is assumed that the SNP1, SNP2,and SNP3 components can be considered as potentially clinically significant markers of cognitive control dis-orders in schizophrenia.
Добавил в систему: Славуцкая Мария Валерьевна

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Slow Negative Potentials in the Pre-Stimulus Period in Healthy Subjects and Patients with their First Episode of Schizophreniaстатья Исследовательская статья

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