Access to Bicyclo[3.1.0]hexane and Cyclopenta[<i>c</i>]pyrazole Scaffolds via Solvent-Directed Divergent Reactivity of 5-Iodotriazoles

Авторы: Barashkova Xenia A., Gevondian Avetik G., Latyshev Gennadij V., Kotovshchikov Yury N., Bezzubov Stanislav I., Lukashev Nikolay V., Beletskaya Irina P.
Журнал: Organic Letters
Том: 26
Номер: 45
Год издания: 2024
Издательство: American Chemical Society
Местоположение издательства: United States
Первая страница: 9625
Последняя страница: 9630
DOI: 10.1021/acs.orglett.4c03082
Аннотация: Divergent access to bicyclo[3.1.0]hexane and cyclopenta[c]pyrazole scaffolds bearing azole and azine units has been developed. The approach involves intramolecular cyclization of 5-iodo-1,2,3-triazoles acting as stable diazoimine precursors with concomitant noncatalytic (3 + 2)-cycloaddition. The choice of solvent allows control of the outcome of the cascade transformation. The developed procedure is simple and cost-efficient and allowed important heterocycles to be obtained in one-pot with various functional groups.
Добавил в систему: Котовщиков Юрий Николаевич

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