Nanoformulation of the Photoactive Cisplatin Prodrug for Combined Photothermal Therapy and Bioimaging

Spector, D.V.; Bykusov, V.; Zharova, A.; Kuzmichev, I.; Isaeva, Y.A.; Khaydukov, E.V.; Trifanova, E.; Stepanov, M.; Erofeev, A.S.; Gorelkin, P.; Kuanaeva, R.; Nikitina, V.N.; Dubenskii, A.; Maksimova, Y.; Skvortsov, D.A.; Ipatova, D.; Rodin, I.A.; Vokuev, M.F.; Martynov, A.G.; Bunin, D.; Pokrovsky, V.S.; Babayeva, G.; Uskova, T.; Abakumov, M.A.; Beloglazkina, E.K.; Akasov, R.A.; Krasnovskaya, O.O.

Авторы: Spector Daniil V., Bykusov Vladislav, Zharova Anastasia, Kuzmichev Ilia, Isaeva Yulia A., Khaydukov Evgeny V., Trifanova Ekaterina, Stepanov Maxim, Erofeev Alexander S., Gorelkin Petr, Kuanaeva Regina, Nikitina Vita N., Dubenskii Alexander, Maksimova Yulia, Skvortsov Dmitry Aleksandrovich, Ipatova Daria, Rodin Igor A., Vokuev Mikhail F., Martynov Alexander G., Bunin Dmitry, Pokrovsky Vadim S., Babayeva Gulalek, Uskova Tamara, Abakumov Maxim A., Beloglazkina Elena K., Akasov Roman A., Krasnovskaya Olga O.
Журнал: ACS Applied Nano Materials
Том: 7
Номер: 22
Год издания: 2024
Издательство: American Chemical Society
Местоположение издательства: United States
Первая страница: 25603
Последняя страница: 25618
DOI: 10.1021/acsanm.4c04680
Аннотация: Cancer phototheranostics is a new mode of precise treatment based on fluorescent and photothermal imaging (PTI), combined with photodynamic (PDT) and photothermal therapy (PTT). Herein, we designed a photoactive Pt(IV) prodrug Pt-1 with BODIPY-based triplet photosensitizer as an axial ligand that exhibits cytotoxic effects through both PDT and photoactivated chemotherapy (PACT). Based on the Pt-1 prodrug, we developed a multifunctional theranostic nanoplatform Pt-NPs with combined PDT/PTT activity, capable of light-induced cisplatin release and suitable for photothermal and fluorescent tumor imaging. Upon 660 nm laser irradiation, Pt-NPs efficiently causes regional hyperpyrexia, with a photothermal conversion efficiency of 42.1%. Synergistically, Pt-NPs acts as a PDT type I agent. In vivo PTI studies have shown bright fluorescence of the CT-26 tumor after intravenous injection of Pt-NPs, indicating accumulation and retention of Pt-NPs in the tumor. This is the first example of PTT/PDT-active NPs based on Pt(IV) prodrug capable of photoinduced release of cisplatin. This strategy of the synergistic light-induced PDT/PTT/PACT action of Pt-NPs provides a new platform for the future design of phototheranostic agents for enhanced tumor treatment and imaging.
Добавил в систему: Красновская Ольга Олеговна

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Nanoformulation of the Photoactive Cisplatin Prodrug for Combined Photothermal Therapy and Bioimagingстатья

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