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Changes of the structure and permeability of lipid membranes caused by nanoparticles and pulsed electromagnetic effectsтезисы доклада
- Авторы: Gulyaev Yu V., Cherepenin A.V., Vdovin V.V., Taranov I.V., Yaroslavov A.A., Potapenkov K.V., Khomutov G.B.
- Сборник: BIOMEMBRANES 2024 International Conference 7 – 11 October 2024 Book of Abstracts
- Тезисы
- Год издания: 2024
- Место издания: Москва
- Первая страница: 102
- Последняя страница: 102
- Аннотация: Currently, a relevant and important interdisciplinary area of science is the development of new highly effective methods of drug therapy aimed at solving the problem of controlled delivery of drugs and genes directly to target areas and cells of the body [1].Our work is devoted to the development of new biocompatible means and methods of encapsulation, targeted delivery and controlled release of drugs in aqueous media including living systems. New nanostructured biomimetic lipid vesicles (nanocomposite liposomes) have been developed, the membranes of which are functionalized with magnetite and gold nanoparticles [2]. As the safe external control physical effects that provide selective remote control of the structure and permeability of the membranes of nanocomposite lipid vesicles, we use non-thermal effects of powerful ultrashort electrical pulses with a duration of less than 10 ns, providing the effect of selective electroporation of lipid membranes containing conductive nanoparticles polarized in an external electric field.The anticancer antibiotic doxorubicin and the fluorescent dye carboxyfluorescein were used as model molecular compounds encapsulated within nanocomposite liposomal carriers and released by the electric pulses.The obtained experimental data and theoretical estimates indicate a controlled activation and increase in the permeability of nanocomposite lipid membranes and an effective release of the encapsulated compound from nanocomposite lipid vesicles as a result of external pulsed electrical action.The study was supported by the Russian Science Foundation (Grant No. 23-12-00125, https://rscf.ru/project/23-12-00125/).1. Koksharov Y.A., Khomutov G.B., Taranov I.V. et al., Magnetic Nanoparticles in Medicine: Progress, Problems, and Advances, Journal of Communications Technology and Electronics (2022). DOI: 10.1134/S10642269220200732. Gulyaev, Y.V., Cherepenin, V.A., Taranov, I.V. Khomutov G.B. et al., Activation of Nanocomposite Liposomal Capsules in a Conductive Water Medium by Ultra-Short Electric Exposure. Journal of Communications Technology and Electronics (2021).DOI: 10.1134/S104226921010022
- Добавил в систему: Потапенков Кирилл Васильевич