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Потенциальные фармакологические эффекты продуктов фотоокисления псоралена и их циклоаддуктов с аминотиолами: хемоинформационный анализстатья
- Авторы: Skarga VV, Zadorozhny AD, Shilov BV, Nevezhin EV, Negrebetsky VV, Maslov MA, Lagunin AA, Malakhov MV
- Журнал: Bulletin of RSMU
- Номер: 2020(5)
- Год издания: 2020
- Издательство: Pirogov Russian National Research Medical University
- Местоположение издательства: Moscow
- DOI: 10.24075/brsmu.2020.059
- Аннотация: Psoralens are medicinal photosensitizing furocoumarins which are used in photochemotherapy and photoimmunotherapy of dermatoses. Psoralen photooxidation products may be involved in therapeutic effects, but the possible mechanisms of their action remain unclear. The study was aimed to assess the prospective pharmacological effects and mechanisms of activity for six previously identified ortho–hydroxyformyl-containing psoralen photooxidation products and their cycloadducts with aminothiols, as well as for structurally similar compounds (furocoumaric acid and tucaresol). Chemoinformatic analysis of the prospective pharmacological effects and mechanisms of action of these compounds was performed using the PASS and PharmaExpert software. The predicted pharmacological effects partially confirmed by previous studies highlight the possible involvement of psoralen photooxidation products in the effects of PUVA therapy or photopheresis during the course of dermatoses and proliferative disorders treatment. A broad spectrum of pharmacological effects found for furocoumaric acid and cycloadducts of coumarinic and benzofuranic photoproducts of psoralen with cysteine and homocysteine appoints new directions of research relating to therapeutic use of psoralens.
- Добавил в систему: Скарга Владислав Викторович