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[Mechanism of the inhibitory effect of acetylcholine and its analogs on sarcolemma Na, K-ATPase]статья
- Авторы: Takachuk V.A., Lopina O.D., Boldyrev A.A.
- Журнал: Biochemistry (Moscow)
- Том: 40
- Номер: 5
- Год издания: 1975
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Аннотация: Effect of acetylcholine on Na, K-ATPase from cardiac and skeletal rabbit muscles is studied. The inhibition of the enzyme by acetylcholine was shown to depend on the Na+/K+ ratio and Mg2+ concentration in the incubation medium. The sensitivity of Na, K-ATPase to acetylcholine and its analogues decreased as follows: acetylcholine, propionylcholine butyrylcholine, arecoline, carbacholine, choline. Muscle denervation resulted in 20-fold increase of the enzyme sensitivity to acetylcholine. Preparations of Na, K-ATPase from different muscles have the increasing sensitivity to acetylcholine in the following order: white, mixed, cardiac, denervated muscles.
- Добавил в систему: Лопина Ольга Дмитриевна